Cephalosporin podand derivatives.
نویسندگان
چکیده
work in the synthesis of podand molecules6), the present paper describes the preparation of certain podand-type trimers of cephalosporin antibiotics (Scheme 1 ). As the central block of the target trimers the tricarboxylic acid 3 was employed, which was obtained by the alkylation of phloroglucinol (1) with methyl bromoacetate and subsequent alkaline hydrolysis. The tert-butyl esters of 7-aminocephalosporanic acid (5)14) and 7pp.1207 1211
منابع مشابه
Effect of methionine, norleucine, and lysine derivatives on cephalosporin C formation in chemically defined media.
Demain, A. L. (Merck Sharp & Dohme Research Laboratories, Rahway, N.J.), Joanne F. Newkirk, and D. Hendlin. Effect of methionine, norleucine, and lysine derivatives on cephalosporin C formation in chemically defined media. J. Bacteriol. 85: 339-344. 1963.-Chemically defined media were developed for production of cephalosporin C by Cephalosporium sp. In such media, the requirement for methionine...
متن کاملPreparation of 7-epi-cephalosporin derivatives.
position 6,1-4) the preparation of 7-epi-aminocephalosporanic 'acid (7a-ACA) has thus far not been reported. Some 7-epi-cephalosporins have been prepared by base-catalyzed epimerization of cephalosporin sulfoxidesu or acidcatalyzed ring expansion of 6-epi-penicillins.e) Both procedures, however, are not convenient for the preparation of 7-epi-cephalosporin derivatives. We wish to report the direct
متن کاملStructure-activity correlations in the cephalosporin C series using extended Hückel theory and CNDO-2.
Using two different molecular orbital methods which treat all valence electrons, namely extended Huckel theory and CNDO/2,a correlation has been found between the biological activity of cephalosporin derivatives and certain aspects of the electronic structure of the /3lactam ring. Electron populations of the carbonyl carbon and bond strength indices of both the carbonyl carbon-nitrogen bond and...
متن کاملSimple and novel synthetic method to mixed-donor podand
An efficient method for the synthesis of new compounds of dibenzo podand containing mixed-donor atom is described. The key starting materials for these podand was successfully prepared in 92% yield from 2aminophenol and benzaldehyde in water. The structures of these new compounds were confirmed on the basis of IR, 1 H NMR and 13 C NMR and Ms spectroscopic data.
متن کاملSynthesis and antibacterial activity of 7-[2-(2-aminooxazol-4-yl)-(Z)-2-alkoxyiminoacetamido]-cephalosporin antibiotics.
In a previous paper3), we reported on the synthesis and the biological activity of 3-methoxymethyl cephalosporin derivatives, one of which, cefpodoxime proxetil (Fig. 1), has been successfully developed as a prodrug for oral use. Our further elaboration for developing orally active cephalosporins has been made in the direction of chemical modification of the C-7 acyl substituent of the 3-methox...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 53 10 شماره
صفحات -
تاریخ انتشار 2000